APEPTICO - Innovation in peptide drugs

Publications

Sieck GC and Wylam ME. Editorial: Paradoxical Use of Tumor Necrosis Factor in Treating Pulmonary Edema. Am J Respir Crit Care Med Vol 190, Iss 6, pp 595-605, Sep 15, 2014.

Czikora I, Alli A, Bao H-F, Kaftan D, Sridhar S, Apell H-J, Gorshkov B, White R, Zimmermann A, Wendel A, et al. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med 2014;190:522-532.

Krenn K, Croize A, Klein KU, Bohme S, Markstaller K, Ullrich R, Hermann R, Lucas R, Fischer B. Oral inhalation of AP301 peptide activates pulmonary oedema clearance: initial results from a phase IIa clinical trial in mechanically ventilated ICU patients. Presented at the ERS International Congress 2014. September 6-10, Munich, Germany.

Hartmann EK, Thomas R, Liu T, Stefaniak J, Ziebart A, Duenges B, Eckle D, Markstaller K, David M. TIP peptide inhalation in experimental acute lung injury: effect of repetitive dosage and different synthetic variants. BMC Anesthesiol 2014;14:42.

Schwameis R, Eder S, Pietschmann H, Fischer B, Mascher H, Tzotzos S, Fischer H, Lucas R, Zeitlinger M, Hermann R. A FIM Study to Assess Safety and Exposure of Inhaled Single Doses of AP301 - a Specific ENaC Channel Activator for the Treatment of Acute Lung Injury. J Clin Pharmacol. 2014 Mar;54(3):341-50. doi:10.1002/jcph.203. PubMed PMID: 24515273.

Shabbir W, Scherbaum-Hazemi P, Tzotzos S, Fischer B, Fischer H, Pietschmann H, Lucas R, Lemmens-Gruber R. Mechanism of Action of Novel Lung Edema Therapeutic AP301 by Activation of the Epithelial Sodium Channel. Mol Pharmacol. 2013 Dec;84(6):899-910. doi: 10.1124/mol.113.089409. Epub 2013 Sep 27. PubMed PMID: 24077967.

Tzotzos S, Fischer B, Fischer H, Pietschmann H, Lucas R, Dupré G, Lemmens-Gruber R, Hazemi P, Prymaka V, Shabbir W. AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na+ current in primary dog, pig and rat alveolar type II cells. Pulm Pharmacol Ther. 2013 Jan 9. doi:pii: S1094-5539(13)00003-5.10.1016/j.pupt.2012.12.011. [Epub ahead of print] PubMed PMID: 23313096.

Hartmann EK, Boehme S, Duenges B, Bentley A, Klein KU, Kwiecien R, Shi C, Szczyrba M, David M, Markstaller K. An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental  lung injury. Acta Anaesthesiol Scand. 2012 Dec 6. doi: 10.1111/aas.12034. [Epub ahead of print] PubMed PMID: 23216436.

Mascher D, Tscherwenka W, Mascher H, Fischer B. Sensitive determination of the peptide AP301--a motif of TNF-α--from human plasma using HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:18-22. doi: 10.1016/j.jchromb.2012.09.028. Epub 2012 Sep 21.

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir  Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10. PubMed PMID: 22582175; PubMed Central PMCID: PMC3488628.

Hazemi P, Tzotzos SJ, Fischer B, Andavan GS, Fischer H, Pietschmann H, Lucas R, Lemmens-Gruber R. Essential structural features of TNF-α lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells. J Med Chem. 2010 Nov 25;53(22):8021-9. doi: 10.1021/jm100767p. Epub 2010 Oct 27. PubMed PMID: 20979368; PubMed Central PMCID: PMC2996585.

Xiong C, Yang G, Kumar S, Aggarwal S, Leustik M, Snead C, Hamacher J, Fischer B, Umapathy NS, Hossain H, Wendel A, Catravas JD, Verin AD, Fulton D, Black SM,Chakraborty T, Lucas R. The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition. Vascul  Pharmacol. 2010 May-Jun;52(5-6):207-13. doi: 10.1016/j.vph.2009.12.010. Epub 2010
Jan 13. PubMed PMID: 20074664.